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Direct demonstration of binding of a lysosomal enzyme, alpha-L-iduronidase, to receptors on cultured fibroblasts.

Receptor-binding of "high-uptake" forms of lysosomal enzymes to human diploid skin fibroblasts had been predicted from the Michaelis--Menten kinetics of uptake of these enzymes [e.g., Sando, G.N. & Neufeld, E.F. (1977) Cell 12, 619--627]. We have now demonstrated such binding directly by using a sen...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rome, L H, Weissmann, B, Neufeld, E F
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383594/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/287076/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.5.2331
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