Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction: A Randomized Clinical Trial

IMPORTANCE: Studies in experimental and human heart failure suggest that phosphodiesterase type-5 inhibitors may enhance cardiovascular function, and thus, exercise capacity in heart failure with preserved ejection fraction. OBJECTIVE: To determine the effect of the phosphodiesterase type-5 inhibito...

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Autori principali: Redfield, Margaret M, Chen, Horng H, Borlaug, Barry A, Semigran, Marc J., Lee, Kerry L., Lewis, Gregory, LeWinter, Martin M., Rouleau, Jean L., Bull, David A., Mann, Douglas L., Deswal, Anita, Stevenson, Lynne W., Givertz, Michael M., Ofili, Elizabeth O., O’Connor, Christopher M., Felker, G. Michael, Goldsmith, Steven R., Bart, Bradley A., McNulty, Steven E, Ibarra, Jenny C., Lin, Grace, Oh, Jae K., Patel, Manesh R., Kim, Raymond J., Tracy, Russell P., Velazquez, Eric J., Anstrom, Kevin J., Hernandez, Adrian F., Mascette, Alice M., Braunwald, Eugene
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835156/
https://ncbi.nlm.nih.gov/pubmed/23478662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2013.2024
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