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Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.

Two groups of mutant clones were isolated from YI adrenocortical tumor cells. One group, Y1(Kin), exhibited altered cytosolic cyclic AMP-dependent protein kinase activity; the second group, Y1(Cyc), exhibited diminished corticotropin-responsive adenylate cyclase activity. Steroidogenic responses to...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rae, P A, Gutmann, N S, Tsao, J, Schimmer, B P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383499/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/221910/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.4.1896
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