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Directed evolution of the TALE N-terminal domain for recognition of all 5′ bases
Transcription activator-like effector (TALE) proteins can be designed to bind virtually any DNA sequence. General guidelines for design of TALE DNA-binding domains suggest that the 5′-most base of the DNA sequence bound by the TALE (the N(0) base) should be a thymine. We quantified the N(0) requirem...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834825/ https://ncbi.nlm.nih.gov/pubmed/23980031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt754 |
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