Increase in Cellular Cyclic AMP Concentrations Reverses the Profibrogenic Phenotype of Cardiac Myofibroblasts: A Novel Therapeutic Approach for Cardiac Fibrosis

Tissue fibrosis is characterized by excessive production, deposition, and contraction of the extracellular matrix (ECM). The second messenger cAMP has antifibrotic effects in fibroblasts from several tissues, including cardiac fibroblasts (CFs). Increased cellular cAMP levels can prevent the transfo...

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Bibliographische Detailangaben
Hauptverfasser: Lu, David, Aroonsakool, Nakon, Yokoyama, Utako, Patel, Hemal H., Insel, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2013
Schlagworte:
Accelerated Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834140/
https://ncbi.nlm.nih.gov/pubmed/24085841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087742
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