A new mechanism of RhoA ubiquitination and degradation: Roles of SCF(FBXL19) E3 ligase and Erk2

RhoA is a small GTPase multifunctional protein that regulates cell proliferation and cytoskeletal reorganization. Regulation of its protein stability plays an important role in its biological functions. We have shown that a Skp1-Cul1-F-box (SCF) FBXL19 E3 ubiquitin ligase targets Rac1, a related mem...

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Bibliografiske detaljer
Main Authors: Wei, Jianxin, Mialki, Rachel K., Dong, Su, Khoo, Andrew, Mallampalli, Rama K., Zhao, Yutong, Zhao, Jing
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834026/
https://ncbi.nlm.nih.gov/pubmed/23871831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.07.005
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