Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours

BACKGROUND: Hypoxia can activate autophagy, a self-digest adaptive process that maintains cell turnover. Mammalian target of rapamycin (mTOR) inhibitors are used to treat cancer but also stimulate autophagy. METHODS: Human mammary cancer cells and derived xenografts were used to examine whether hypo...

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Dettagli Bibliografici
Autori principali: Seront, E, Boidot, R, Bouzin, C, Karroum, O, Jordan, B F, Gallez, B, Machiels, J-P, Feron, O
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833227/
https://ncbi.nlm.nih.gov/pubmed/24157830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.644
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