Subtoxic Levels of Apigenin Inhibit Expression and Secretion of VEGF by Uveal Melanoma Cells via Suppression of ERK1/2 and PI3K/Akt Pathways

The effects of apigenin on the expression of VEGF in uveal melanoma cells have not been reported. We studied this effect and relevant signaling pathways in two human uveal melanoma cell lines (SP6.5 and C918). ELISA assay revealed that the constitutive secretion of VEGF by uveal melanoma cells was 2...

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Bibliographische Detailangaben
Hauptverfasser: Chao, Shih-Chun, Huang, Sheng-Chieh, Hu, Dan-Ning, Lin, Hung-Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833119/
https://ncbi.nlm.nih.gov/pubmed/24288566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/817674
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