Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.

Plasmodium falciparum is the major causative agent of malaria, a disease of worldwide importance. Resistance to current drugs such as chloroquine and mefloquine is spreading at an alarming rate, and our antimalarial armamentarium is almost depleted. The malarial parasite encodes two homologous aspar...

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Dades bibliogràfiques
Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Silva, A M, Lee, A Y, Gulnik, S V, Maier, P, Collins, J, Bhat, T N, Collins, P J, Cachau, R E, Luker, K E, Gluzman, I Y, Francis, S E, Oksman, A, Goldberg, D E, Erickson, J W
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1996
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38331/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816746/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10034
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Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.

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