Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target

The dismal outcome of blast crisis chronic myelogenous leukemia (CML-BC) patients underscores the need for a better understanding of the mechanisms responsible for the development of drug-resistance. Altered expression of the anti-apoptotic Bcl-xL has been correlated with BCR-ABL leukemogenesis; how...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Harb, J.G., Neviani, P., Chyla, B.J., Ellis, J.E., Ferenchak, G.J., Oaks, J.J., Walker, C. J., Hokland, P., Roy, DC, Caligiuri, M.A., Marcucci, G., Huettner, C.S., Perrotti, D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833002/
https://ncbi.nlm.nih.gov/pubmed/23670294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.151
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