Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the development of pathogenic anti-RNA autoantibodies both in systemic lupus erythematous (SLE) patients and in murine models of lupus. It is still unclear, however, where and how TLR7-mediated interactions affect the...

Full description

Saved in:
Bibliographic Details
Main Authors: Giltiay, Natalia V., Chappell, Craig P., Sun, Xizhang, Kolhatkar, Nikita, Teal, Thomas H., Wiedeman, Alice E., Kim, Jinoh, Tanaka, Lena, Buechler, Matthew B., Hamerman, Jessica A., Imanishi-Kari, Thereza, Clark, Edward A., Elkon, Keith B.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832927/
https://ncbi.nlm.nih.gov/pubmed/24145511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122798
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items