Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the development of pathogenic anti-RNA autoantibodies both in systemic lupus erythematous (SLE) patients and in murine models of lupus. It is still unclear, however, where and how TLR7-mediated interactions affect the...

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Hauptverfasser: Giltiay, Natalia V., Chappell, Craig P., Sun, Xizhang, Kolhatkar, Nikita, Teal, Thomas H., Wiedeman, Alice E., Kim, Jinoh, Tanaka, Lena, Buechler, Matthew B., Hamerman, Jessica A., Imanishi-Kari, Thereza, Clark, Edward A., Elkon, Keith B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832927/
https://ncbi.nlm.nih.gov/pubmed/24145511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122798
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