Plxnd1 Expression in Thymocytes Regulates Their Intrathymic Migration While That in Thymic Endothelium Impacts Medullary Topology

An important role for plexinD1 in thymic development is inferred from studies of germline Plxnd1 knockout (KO) mice where mislocalized CD69(+) thymocytes as well as ectopic thymic subcapsular medullary structures were observed. Given embryonic lethality of the Plxnd1(−/−) genotype, fetal liver trans...

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Autores principales: Choi, Young I., Duke-Cohan, Jonathan S., Tan, Jing, Gui, Jingang, Singh, Manvendra K., Epstein, Jonathan A., Reinherz, Ellis L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832804/
https://ncbi.nlm.nih.gov/pubmed/24312099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00392
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