Global Phosphotyrosine Proteomics Identifies PKCδ as a Marker of Responsiveness to Src Inhibition in Colorectal Cancer

Sensitive and specific biomarkers of protein kinase inhibition can be leveraged to accelerate drug development studies in oncology by associating early molecular responses with target inhibition. In this study, we utilized unbiased shotgun phosphotyrosine (pY) proteomics to discover novel biomarkers...

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Bibliografske podrobnosti
Main Authors: McKinley, Eliot T., Liu, Huiling, McDonald, W. Hayes, Luo, Weifeng, Zhao, Ping, Coffey, Robert J., Hanks, Steven K., Manning, H. Charles
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832668/
https://ncbi.nlm.nih.gov/pubmed/24260357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080207
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