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Global Phosphotyrosine Proteomics Identifies PKCδ as a Marker of Responsiveness to Src Inhibition in Colorectal Cancer

Sensitive and specific biomarkers of protein kinase inhibition can be leveraged to accelerate drug development studies in oncology by associating early molecular responses with target inhibition. In this study, we utilized unbiased shotgun phosphotyrosine (pY) proteomics to discover novel biomarkers...

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Détails bibliographiques
Auteurs principaux: McKinley, Eliot T., Liu, Huiling, McDonald, W. Hayes, Luo, Weifeng, Zhao, Ping, Coffey, Robert J., Hanks, Steven K., Manning, H. Charles
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832668/
https://ncbi.nlm.nih.gov/pubmed/24260357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080207
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