Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions

Epigallocatechin-3-gallate (EGCG), a dietary polyphenol (flavanol) from green tea, possesses leishmanicidal and antitrypanosomal activity. Mitochondrial damage was observed in Leishmania treated with EGCG, and it contributed to the lethal effect. However, the molecular target has not been defined. I...

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Main Authors: dos Reis, Matheus Balduíno Goncalves, Manjolin, Letícia Correa, Maquiaveli, Claudia do Carmo, Santos-Filho, Osvaldo Andrade, da Silva, Edson Roberto
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832641/
https://ncbi.nlm.nih.gov/pubmed/24260115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078387
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