Inhibition of Leishmania (Leishmania) amazonensis and Rat Arginases by Green Tea EGCG, (+)-Catechin and (−)-Epicatechin: A Comparative Structural Analysis of Enzyme-Inhibitor Interactions

Epigallocatechin-3-gallate (EGCG), a dietary polyphenol (flavanol) from green tea, possesses leishmanicidal and antitrypanosomal activity. Mitochondrial damage was observed in Leishmania treated with EGCG, and it contributed to the lethal effect. However, the molecular target has not been defined. I...

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Main Authors: dos Reis, Matheus Balduíno Goncalves, Manjolin, Letícia Correa, Maquiaveli, Claudia do Carmo, Santos-Filho, Osvaldo Andrade, da Silva, Edson Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832641/
https://ncbi.nlm.nih.gov/pubmed/24260115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078387
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