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Roscovitine Suppresses CD4+ T Cells and T Cell-Mediated Experimental Uveitis
BACKGROUND: T cells are essential for the development of uveitis and other autoimmune diseases. After initial activation, CD4+ lymphocytes express the co-stimulatory molecule OX40 that plays an important role in T cell proliferation. Cyclin dependent kinase 2 (CdK2) plays a pivotal role in the cell...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3832440/ https://ncbi.nlm.nih.gov/pubmed/24260551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081154 |
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