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Combining two strategies to improve perfusion and drug delivery in solid tumors

Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a hypoxic microenvironment. Hypoxia promotes tumor progression and immunosuppressi...

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Detalhes bibliográficos
Main Authors: Stylianopoulos, Triantafyllos, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832007/
https://ncbi.nlm.nih.gov/pubmed/24167277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318415110
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