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Ca(2+) ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways

Ca(2+) ionophore A23187 is known to induce the acrosome reaction of mammalian spermatozoa, but it also quickly immobilizes them. Although mouse spermatozoa were immobilized by this ionophore, they initiated vigorous motility (hyperactivation) soon after this reagent was washed away by centrifugation...

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Detalhes bibliográficos
Main Authors: Tateno, Hiroyuki, Krapf, Dario, Hino, Toshiaki, Sánchez-Cárdenas, Claudia, Darszon, Alberto, Yanagimachi, Ryuzo, Visconti, Pablo E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831971/
https://ncbi.nlm.nih.gov/pubmed/24128762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317113110
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