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Mechanistic analysis of the function of agonists and allosteric modulators: reconciling two-state and operational models
Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3831701/ https://ncbi.nlm.nih.gov/pubmed/23647200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12231 |
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