The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons

The NO-cGMP signaling plays an important role in the regulation of striatal function although the mechanisms of action of cGMP specifically in medium spiny neurons (MSNs) remain unclear. Using genetically encoded fluorescent biosensors, including a novel Epac-based sensor (EPAC-S(H150)) with increas...

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Detalhes bibliográficos
Main Authors: Polito, Marina, Klarenbeek, Jeffrey, Jalink, Kees, Paupardin-Tritsch, Danièle, Vincent, Pierre, Castro, Liliana R.V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831346/
https://ncbi.nlm.nih.gov/pubmed/24302895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00211
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