The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons

The NO-cGMP signaling plays an important role in the regulation of striatal function although the mechanisms of action of cGMP specifically in medium spiny neurons (MSNs) remain unclear. Using genetically encoded fluorescent biosensors, including a novel Epac-based sensor (EPAC-S(H150)) with increas...

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Main Authors: Polito, Marina, Klarenbeek, Jeffrey, Jalink, Kees, Paupardin-Tritsch, Danièle, Vincent, Pierre, Castro, Liliana R.V.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831346/
https://ncbi.nlm.nih.gov/pubmed/24302895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00211
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