NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

With NADPH as the electron donor, rat liver NADPH cytochrome P-450 reductase (NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) catalyzes the single-electron reduction of several quinone antibiotics to a semiquinone or free radical state. The benzanthraquinones adriamycin, daunorubicin, carminomycin...

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Autors principals: Bachur, N R, Gordon, S L, Gee, M V, Kon, H
Format: Artigo
Idioma:Inglês
Publicat: 1979
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC383104/
https://ncbi.nlm.nih.gov/pubmed/34156
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