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Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development
Neuronal arborization is regulated by cell autonomous and non-autonomous mechanisms including endosomal signaling via BDNF/TrkB. The endosomal Na(+)/H(+) exchanger 6 (NHE6) is mutated in a new autism-related disorder. NHE6 functions to permit proton leak from endosomes yet the mechanisms causing dis...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3830955/ https://ncbi.nlm.nih.gov/pubmed/24035762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.07.043 |
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