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Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells

The mutagenicity of 7,12-dimethylbenz[a]-anthracene (DMBA) and 11 of its enzymatically derived metabolites was tested with Chinese hamster V79 cells for identification of mutagenic metabolites. The metabolites consisted of 7-hydroxymethyl-12-methylbenz[a]anthracene, 7-methyl-12-hydroxymethylbenz[a]a...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Huberman, Eliezer, Chou, Ming W., Yang, Shen K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1979
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383073/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/106395/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.2.862
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