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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent kinases, its kinase activity is detected only in the postmitotic neurons. Cdk5 expression and kinase activity are correlated with the extent of differentiation of neuronal cells in developing brain. Cdk5 purified...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ohshima, T, Ward, J M, Huh, C G, Longenecker, G, Veeranna, Pant, H C, Brady, R O, Martin, L J, Kulkarni, A B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38303/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855328/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.11173
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