Do cleavages of amides by serine proteases occur through a stepwise pathway involving tetrahedral intermediates?
The mechanism of the serine protease-catalyzed cleavage of amides (acylation) was examined in terms of the basicity of the functional groups participating in the catalysis. It is proposed that the reaction does not proceed through a stepwise pathway, as opposed to the cleavage of esters and anilides...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1979
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC382987/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/284381/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.2.557 |
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