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Do cleavages of amides by serine proteases occur through a stepwise pathway involving tetrahedral intermediates?
The mechanism of the serine protease-catalyzed cleavage of amides (acylation) was examined in terms of the basicity of the functional groups participating in the catalysis. It is proposed that the reaction does not proceed through a stepwise pathway, as opposed to the cleavage of esters and anilides...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1979
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC382987/ https://ncbi.nlm.nih.gov/pubmed/284381 |
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