Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns that mediate well established cytokine-driven pathways, activating NF-κB together with IRF3/IRF7. In addition, TLR3 drives caspase 8-regulated programmed cell death pathways reminiscent of TNF family death rece...

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Bibliographic Details
Main Authors: Kaiser, William J., Sridharan, Haripriya, Huang, Chunzi, Mandal, Pratyusha, Upton, Jason W., Gough, Peter J., Sehon, Clark A., Marquis, Robert W., Bertin, John, Mocarski, Edward S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829437/
https://ncbi.nlm.nih.gov/pubmed/24019532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.462341
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