Characterization of a Nodavirus Replicase Revealed a de Novo Initiation Mechanism of RNA Synthesis and Terminal Nucleotidyltransferase Activity

Nodaviruses are a family of positive-stranded RNA viruses with a bipartite genome of RNAs. In nodaviruses, genomic RNA1 encodes protein A, which is recognized as an RNA-dependent RNA polymerase (RdRP) and functions as the sole viral replicase protein responsible for its RNA replication. Although nod...

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Detalhes bibliográficos
Main Authors: Wang, Zhaowei, Qiu, Yang, Liu, Yongxiang, Qi, Nan, Si, Jie, Xia, Xiaoling, Wu, Di, Hu, Yuanyang, Zhou, Xi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829395/
https://ncbi.nlm.nih.gov/pubmed/24019510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492728
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