UV-triggered Affinity Capture Identifies Interactions between the Plasmodium falciparum Multidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells

A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reactive affinity capture method to find parasite proteins specifically interacting with the capture com...

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Main Authors: Brunner, Ralf, Ng, Caroline L., Aissaoui, Hamed, Akabas, Myles H., Boss, Christoph, Brun, Reto, Callaghan, Paul S., Corminboeuf, Olivier, Fidock, David A., Frame, Ithiel J., Heidmann, Bibia, Le Bihan, Amélie, Jenö, Paul, Mattheis, Corinna, Moes, Suzette, Müller, Ingrid B., Paguio, Michelle, Roepe, Paul D., Siegrist, Romain, Voss, Till, Welford, Richard W. D., Wittlin, Sergio, Binkert, Christoph
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829344/
https://ncbi.nlm.nih.gov/pubmed/23754276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453159
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