Mice Lacking C1q Are Protected from High Fat Diet-induced Hepatic Insulin Resistance and Impaired Glucose Homeostasis

Complement activation is implicated in the development of obesity and insulin resistance, and loss of signaling by the anaphylatoxin C3a prevents obesity-induced insulin resistance in mice. Here we have identified C1q in the classical pathway as required for activation of complement in response to h...

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Detalhes bibliográficos
Main Authors: Hillian, Antoinette D., McMullen, Megan R., Sebastian, Becky M., Rowchowdhury, Sanjoy, Kashyap, Sangeeta R., Schauer, Philip R., Kirwan, John P., Feldstein, Ariel E., Nagy, Laura E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829343/
https://ncbi.nlm.nih.gov/pubmed/23788643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.465674
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