Structural and Biochemical Characterization of an Active Arylamine N-Acetyltransferase Possessing a Non-canonical Cys-His-Glu Catalytic Triad

Arylamine N-acetyltransferases (NATs), a class of xenobiotic-metabolizing enzymes, catalyze the acetylation of aromatic amine compounds through a strictly conserved Cys-His-Asp catalytic triad. Each residue is essential for catalysis in both prokaryotic and eukaryotic NATs. Indeed, in (HUMAN)NAT2 va...

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Autores principales: Kubiak, Xavier, Li de la Sierra-Gallay, Inès, Chaffotte, Alain F., Pluvinage, Benjamin, Weber, Patrick, Haouz, Ahmed, Dupret, Jean-Marie, Rodrigues-Lima, Fernando
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829337/
https://ncbi.nlm.nih.gov/pubmed/23770703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468595
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