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Generating S-Nitrosothiols from Hemoglobin: MECHANISMS, CONFORMATIONAL DEPENDENCE, AND PHYSIOLOGICAL RELEVANCE

In vitro, ferrous deoxy-hemes in hemoglobin (Hb) react with nitrite to generate nitric oxide (NO) through a nitrite reductase reaction. In vivo studies indicate Hb with nitrite can be a source of NO bioactivity. The nitrite reductase reaction does not appear to account fully for this activity becaus...

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Autori principali: Roche, Camille J., Cassera, Maria B., Dantsker, David, Hirsch, Rhoda Elison, Friedman, Joel M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829331/
https://ncbi.nlm.nih.gov/pubmed/23775069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482679
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