Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1

BACKGROUND: Endothelial dysfunction is an early sign of diabetic cardiovascular disease and may contribute to progressive diabetic nephropathy (DN). There is increasing evidence that dysfunction of the endothelial tight junction is a crucial step in the development of endothelial hyperpermeability,...

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Main Authors: Peng, Hui, Luo, Pengli, Li, Yuanqing, Wang, Cheng, Liu, Xun, Ye, Zengchun, Li, Canming, Lou, Tanqi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828237/
https://ncbi.nlm.nih.gov/pubmed/24244596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080009
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