Morphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo

BACKGROUND: Pain and renal dysfunction occur in sickle cell disease. Morphine used to treat pain also co-activates platelet-derived growth factor receptor-β (PDGFR-β), which can adversely affect renal disease. We examined the influence of morphine in mesangial cells in vitro and in mouse kidneys in...

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Autors principals: Weber, M. L., Chen, C., Li, Y., Farooqui, M., Nguyen, J., Poonawala, T., Hebbel, R. P., Gupta, K.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Translational Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828056/
https://ncbi.nlm.nih.gov/pubmed/23820675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bja/aet221
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