Gastrointestinal stromal tumors: a case-only analysis of single nucleotide polymorphisms and somatic mutations

BACKGROUND: Gastrointestinal stromal tumors are rare soft tissue sarcomas that typically develop from mesenchymal cells with acquired gain-in-function mutations in KIT or PDGFRA oncogenes. These somatic mutations have been well-characterized, but little is known about inherited genetic risk factors....

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: O’Brien, Katie M, Orlow, Irene, Antonescu, Cristina R, Ballman, Karla, McCall, Linda, DeMatteo, Ronald, Engel, Lawrence S
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827940/
https://ncbi.nlm.nih.gov/pubmed/24159917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3329-3-12
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