The impact of Folate Pathway Polymorphisms Combined to Nutritional Deficiency As a Maternal Predisposition Factor for Down Syndrome

Polymorphisms in genes encoding folate metabolizing enzymes have been linked to an increased risk of maternal chromosomal nondisjunction in several populations. With the purpose of evaluating this relationship, we compared the frequencies of 677C>T and 1298A>C polymorphisms in the methylenetet...

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Autors principals: Santos-Rebouças, C. B., Corrêa, J. C., Bonomo, A., Fintelman-Rodrigues, N., Moura, K. C. V., Rodrigues, C. S. C., Santos, J. M., Pimentel, M. M. G.
Format: Artigo
Idioma:Inglês
Publicat: IOS Press 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827818/
https://ncbi.nlm.nih.gov/pubmed/19096127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/487023
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