Genetic Deletion of Afadin Causes Hydrocephalus by Destruction of Adherens Junctions in Radial Glial and Ependymal Cells in the Midbrain

Adherens junctions (AJs) play a role in mechanically connecting adjacent cells to maintain tissue structure, particularly in epithelial cells. The major cell–cell adhesion molecules at AJs are cadherins and nectins. Afadin binds to both nectins and α-catenin and recruits the cadherin-β-catenin compl...

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Bibliographic Details
Main Authors: Yamamoto, Hideaki, Maruo, Tomohiko, Majima, Takashi, Ishizaki, Hiroyoshi, Tanaka-Okamoto, Miki, Miyoshi, Jun, Mandai, Kenji, Takai, Yoshimi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827428/
https://ncbi.nlm.nih.gov/pubmed/24236178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080356
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