Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B.

Cytotoxic T lymphocytes (CTL) can induce apoptosis through a granzyme B-based killing mechanism. Here we show that in cells undergoing apoptosis by granzyme B, both p45 pro-interleukin 1 beta converting enzyme (ICE) and pro-CPP32 are processed. Using ICE deficient (ICE -/-) mice, embryonic fibroblas...

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Autori principali: Shi, L, Chen, G, MacDonald, G, Bergeron, L, Li, H, Miura, M, Rotello, R J, Miller, D K, Li, P, Seshadri, T, Yuan, J, Greenberg, A H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC38273/
https://ncbi.nlm.nih.gov/pubmed/8855298
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