Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations

BACKGROUND: Increased number of single nucleotide substitutions is seen in breast and ovarian cancer genomes carrying disease-associated mutations in BRCA1 or BRCA2. The significance of these genome-wide mutations is unknown. We hypothesize genome-wide mutation burden mirrors deficiencies in DNA rep...

Full description

Saved in:
Bibliographic Details
Main Authors: Birkbak, Nicolai Juul, Kochupurakkal, Bose, Izarzugaza, Jose M. G., Eklund, Aron C., Li, Yang, Liu, Joyce, Szallasi, Zoltan, Matulonis, Ursula A., Richardson, Andrea L., Iglehart, J. Dirk, Wang, Zhigang C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827141/
https://ncbi.nlm.nih.gov/pubmed/24265793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080023
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items