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Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination

Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative eff...

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Bibliografiske detaljer
Main Authors: Litterman, Adam J, Dudek, Arkadiusz Z, Largaespada, David A
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827073/
https://ncbi.nlm.nih.gov/pubmed/24251080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26294
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