Recombinant lentogenic Newcastle disease virus expressing Ebola virus GP infects cells independently of exogenous trypsin and uses macropinocytosis as the major pathway for cell entry

BACKGROUND: Using reverse genetics, we generated a recombinant low-pathogenic LaSota strain Newcastle disease virus (NDV) expressing the glycoprotein (GP) of Ebola virus (EBOV), designated rLa-EBOVGP, and evaluated its biological characteristic in vivo and in vitro. RESULTS: The introduction and exp...

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Main Authors: Wen, Zhiyuan, Zhao, Bolin, Song, Kun, Hu, Xule, Chen, Weiye, Kong, Dongni, Ge, Jinying, Bu, Zhigao
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826533/
https://ncbi.nlm.nih.gov/pubmed/24209904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-331
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