Syndecan-2 Exerts Antifibrotic Effects by Promoting Caveolin-1–mediated Transforming Growth Factor-β Receptor I Internalization and Inhibiting Transforming Growth Factor-β1 Signaling

Rationale: Alveolar transforming growth factor (TGF)-β1 signaling and expression of TGF-β1 target genes are increased in patients with idiopathic pulmonary fibrosis (IPF) and in animal models of pulmonary fibrosis. Internalization and degradation of TGF-β receptor TβRI inhibits TGF-β signaling and c...

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Main Authors: Shi, Yuanyuan, Gochuico, Bernadette R., Yu, Guoying, Tang, Xiaomeng, Osorio, Juan C., Fernandez, Isis E., Risquez, Cristobal F., Patel, Avignat S., Shi, Ying, Wathelet, Marc G., Goodwin, Andrew J., Haspel, Jeffrey A., Ryter, Stefan W., Billings, Eric M., Kaminski, Naftali, Morse, Danielle, Rosas, Ivan O.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826270/
https://ncbi.nlm.nih.gov/pubmed/23924348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201303-0434OC
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