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Liddle’s syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface
The epithelial Na(+) channel (ENaC) plays a critical role in Na(+) absorption, and mutations in this channel cause diseases of Na(+) homeostasis, including a genetic form of hypertension (Liddle’s syndrome). To investigate cAMP-mediated stimulation of ENaC, α, β, and γENaC were coexpressed in Fische...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC382584/ https://ncbi.nlm.nih.gov/pubmed/10619860 |
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