Homocysteine-Induced Apoptosis in Endothelial Cells Coincides With Nuclear NOX2 and Peri-nuclear NOX4 Activity

Apoptosis of endothelial cells related to homocysteine (Hcy) has been reported in several studies. In this study, we evaluated whether reactive oxygen species (ROS)-producing signaling pathways contribute to Hcy-induced apoptosis induction, with specific emphasis on NADPH oxidases. Human umbilical v...

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Main Authors: Sipkens, Jessica A., Hahn, Nynke, van den Brand, Carlien S., Meischl, Christof, Cillessen, Saskia A. G. M., Smith, Desirée E. C., Juffermans, Lynda J. M., Musters, René J. P., Roos, Dirk, Jakobs, Cornelis, Blom, Henk J., Smulders, Yvo M., Krijnen, Paul A. J., Stehouwer, Coen D. A., Rauwerda, Jan A., van Hinsbergh, Victor W. M., Niessen, Hans W. M.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2011
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825580/
https://ncbi.nlm.nih.gov/pubmed/22038300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12013-011-9297-y
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