Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients

Pro-coagulant and pro-inflammatory intramyocardial (micro)vasculature plays an important role in acute myocardial infarction (AMI). Currently, inhibition of serine protease dipeptidyl peptidase 4 (DPP4) receives a lot of interest as an anti-hyperglycemic therapy in type 2 diabetes patients. However,...

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Detalles Bibliográficos
Main Authors: Krijnen, Paul A. J., Hahn, Nynke E., Kholová, Ivana, Baylan, Umit, Sipkens, Jessica A., van Alphen, Floris P., Vonk, Alexander B. A., Simsek, Suat, Meischl, Christof, Schalkwijk, Casper G., van Buul, Jaap D., van Hinsbergh, Victor W. M., Niessen, Hans W. M.
Formato: Artigo
Idioma:Inglês
Publicado: Springer-Verlag 2011
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Original Contribution
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252036/
https://ncbi.nlm.nih.gov/pubmed/22167343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-011-0233-5
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