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Ligand-activated site-specific recombination in mice.

Current mouse gene targeting technology is unable to introduce somatic mutations at a chosen time and/or in a given tissue. We report here that conditional site-specific recombination can be achieved in mice using a new version of the Cre/lox system. The Cre recombinase has been fused to a mutated l...

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Autori principali: Feil, R, Brocard, J, Mascrez, B, LeMeur, M, Metzger, D, Chambon, P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC38252/
https://ncbi.nlm.nih.gov/pubmed/8855277
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