Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells

Epithelial–mesenchymal transition (EMT) is a crucial step in tumor progression, and the TGFβ–SMAD signaling pathway as an inductor of EMT in many tumor types is well recognized. However, the role of non-canonical TGFβ–TAK1 signaling in EMT remains unclear. Herein, we show that TAK1 deficiency drives...

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Autors principals: Lam, C R I, Tan, C, Teo, Z, Tay, C Y, Phua, T, Wu, Y L, Cai, P Q, Tan, L P, Chen, X, Zhu, P, Tan, N S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824649/
https://ncbi.nlm.nih.gov/pubmed/24113182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.339
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