DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals

Human-nucleotide-excision repair (NER) deficiency leads to different developmental and segmental progeroid symptoms of which the pathogenesis is only partially understood. To understand the biological impact of accumulating spontaneous DNA damage, we studied the phenotypic consequences of DNA-repair...

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Detalhes bibliográficos
Main Authors: Lans, H, Lindvall, J M, Thijssen, K, Karambelas, A E, Cupac, D, Fensgård, Ø, Jansen, G, Hoeijmakers, J H J, Nilsen, H, Vermeulen, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824592/
https://ncbi.nlm.nih.gov/pubmed/24013725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.126
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