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Steady state production of IL-4 modulates immunity in different strains and is determined by lineage diversity of iNKT cells

iNKT cells can produce high levels of IL-4 early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we define 3 subsets of iNKT cells that produce distinct cytokines (NKT...

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Autori principali: Lee, You Jeong, Holzapfel, Keli L., Zhu, Jinfang, Jameson, Stephen C., Hogquist, Kristin A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824254/
https://ncbi.nlm.nih.gov/pubmed/24097110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2731
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